Contributions of multiple factors in explaining observed structural connectivity. (a) Illustration of connectivity matrices encoding observed streamline counts, physical closeness of regions, and genetic similarity between region. The matrices depict the strength of connectivity between regions, as measured by different factors. Rows and columns correspond to regions in the same order. Connectivity matrices are averaged across multiple participants and normalized to the range 0-1 for visualization purposes. (b) Coefficients of different factors in the generative model. Box plots summarize values across all participants. (c) The proportion of explained connectivity by models including different sets of factors. The models including modules and hubs also include closeness and genetic similarity factors. (d) Comparisons of mean values between three models, namely the base model (closeness and genes), the modular model, and the modular yet integrative model.